Mexico City is the capital and largest city of Mexico, and the most populous city in North America. It is one of the most important cultural and financial centers in the world. Mexico City is located in the Valley of Mexico within the high Mexican central plateau, at an altitude of 2,240 meters (7,350 ft). The city has 16 boroughs or demarcaciones territoriales, which are in turn divided into neighborhoods or colonias.

The 2020 population for the city proper was 9,209,944, with a land area of 1,495 square kilometers (577 sq mi). According to the most recent definition agreed upon by the federal and state governments, the population of Greater Mexico City is 21,804,515, which makes it the sixth-largest metropolitan area in the world, the second-largest urban agglomeration in the Western Hemisphere (behind São Paulo, Brazil), and the largest Spanish-speaking city (city proper) in the world. Greater Mexico City has a GDP of $411 billion in 2011, which makes it one of the most productive urban areas in the world. The city was responsible for generating 15.8% of Mexico's GDP, and the metropolitan area accounted for about 22% of the country's GDP. If it were an independent country in 2013, Mexico City would be the fifth-largest economy in Latin America.

Mexico City is the oldest capital city in the Americas and one of two founded by Indigenous people. The city was originally built on a group of islands in Lake Texcoco by the Mexica around 1325, under the name Tenochtitlan. It was almost completely destroyed in the 1521 siege of Tenochtitlan and subsequently redesigned and rebuilt in accordance with the Spanish urban standards. In 1524, the municipality of Mexico City was established, known as México Tenochtitlán, and as of 1585, it was officially known as Ciudad de México (Mexico City). Mexico City played a major role in the Spanish colonial empire as a political, administrative, and financial center. Following independence from Spain, the federal district was established in 1824.

After years of demanding greater political autonomy, residents were finally given the right to elect both a head of government and the representatives of the unicameral Legislative Assembly by election in 1997. Ever since, left-wing parties (first the Party of the Democratic Revolution and later the National Regeneration Movement) have controlled both of them. The city has several progressive policies, such as elective abortions, a limited form of euthanasia, no-fault divorce, same-sex marriage, and legal gender change. On 29 January 2016, it ceased to be the Federal District (Spanish: Distrito Federal or D.F.) and is now officially known as Ciudad de México (or CDMX), with a greater degree of autonomy. A clause in the Constitution of Mexico, however, prevents it from becoming a state within the Mexican federation, as long it remains the capital of the country.