- Santa Cruz (Argentina) - a province in the Patagonia (Argentina) region
- Santa Cruz (department, Bolivia) - Bolivia's largest department
- Santa Cruz (city, Bolivia) - capital city of Santa Cruz (department, Bolivia)
- Santa Cruz, Espírito Santo
- Santa Cruz, Paraíba
- Santa Cruz, Pernambuco
- Santa Cruz, Rio Grande do Norte
- Santa Cruz do Arari, Pará
- Santa Cruz da Baixa Verde, Pernambuco
- Santa Cruz Cabrália, Bahia
- Santa Cruz do Capibaribe, Pernambuco
- Santa Cruz da Conceição, São Paulo
- Santa Cruz do Escalvado, Minas Gerais
- Santa Cruz da Esperança, São Paulo
- Santa Cruz de Goiás, Goiás
- Santa Cruz dos Milagres, Piauí
- Santa Cruz de Minas, Minas Gerais
- Santa Cruz de Monte Castelo, Paraná
- Santa Cruz das Palmeiras, São Paulo
- Santa Cruz do Piauí, Piauí
- Santa Cruz do Rio Pardo, São Paulo
- Santa Cruz de Salinas, Minas Gerais
- Santa Cruz do Sul, Rio Grande do Sul
- Santa Cruz da Vitória, Bahia
- Santa Cruz Canton, Guanacaste Province
- Santa Cruz, Costa Rica
- Santa Cruz (Galapagos) (Isla Santa Cruz, or Indefatigable Island) - one of the Galapagos Islands
- Santa Cruz (Mumbai) - a suburb of Mumbai
- Santa Cruz (Goa) - a town in Goa (state)
- Santa Cruz de Juventino Rosas
- Santa Cruz, Sonora
- Santa Cruz de Flores, Lima Region
- Santa Cruz Province, Peru
- Santa Cruz, Davao del Sur
- Santa Cruz, Ilocos Sur
- Santa Cruz (Laguna)
- Santa Cruz (Manila) - A district of Manila.
- Santa Cruz (Marinduque)
- Santa Cruz, Occidental Mindoro
- Santa Cruz, Zambales
- Santa Cruz (Madeira) - a city on Madeira Island, in the Madeira archipelago
- Santa Cruz, Almodôvar, Portugal
- Santa Cruz (Armamar), a parish in the district of Armamar
- Santa Cruz (Coimbra), a parish in the district of Coimbra
- Santa Cruz, Portugal, a parish and a district
- Santa Cruz (Santiago do Cacém), a parish in the district of Santiago do Cacém
- Santa Cruz (Vinhais), a parish in the district of Vinhais
- Santa Cruz das Flores, a borough on the island of Flores
- Santa Cruz (Azores), a parish in the district of Lagoa
- Santa Cruz Islands - an archipelago forming part of the Solomon Islands
- Santa Cruz de Tenerife - capital city of the island of Tenerife, and joint capital (with Las Palmas de Gran Canaria) of the Canary Islands
- Santa Cruz de La Palma - largest city of the island of La Palma
- Santa Cruz del Valle de los Caídos, Madrid
- Santa Cruz de Boedo municipality Palencia
- Santa Cruz de Bezana Cantabria
- Santa Cruz del Grío municipality Zaragoza
- Santa Cruz de la Salceda, municipality Burgos
- Santa Cruz de la Serós, municipality Huesca
- Santa Cruz de Tenerife (province)
- Santa Cruz de La Palma, Canary Islands
- Santa Cruz (California) - a city in Santa Cruz County, in the Bay Area region of California
- Santa Cruz (New Mexico) - a town in Santa Fe County, North Central New Mexico
- Santa Cruz (Texas) - a town in the South Texas Plains, Texas
- Santa Cruz County (Arizona) - in South Central Arizona
- Santa Cruz County (California) - in the Bay Area region of California
- Santa Cruz Island - the largest of the five islands that make up the Channel Islands National Park, in Southern California
- Santa Cruz Mountains - a mountain range in central California
- Santa Cruz del Zulia
- Santa Cruz, Aragua
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