- San Sebastian (Puerto Rico) (San Sebastián) - a municipality
- San Sebastián (Donostia) - provincial capital of Guipuzcoa, in the Basque Country
- San Sebastian de La Gomera - capital of La Gomera, one of the Canary Islands
- Sebastian - a city in Indian River County, in the Treasure Coast region of Florida
- Sebastian (Texas) - a place in Willacy County, Gulf Coast (Texas)
- Sebastian County - in the Ouachitas region of Arkansas
- Sebastian Inlet State Park - in the Treasure Coast region of Florida
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